可穿戴计算机
连续血糖监测
费斯特共振能量转移
持续监测
生物医学工程
材料科学
纳米技术
计算机科学
工程类
嵌入式系统
医学
物理
光学
1型糖尿病
运营管理
荧光
糖尿病
内分泌学
作者
Yubing Hu,Zhisheng Pan,Maarten De Bock,Tat Chin Tan,Yuhuai Wang,Yuqi Shi,Neng Yan,Ali K. Yetisen
标识
DOI:10.1016/j.bios.2024.116542
摘要
Continuous glucose monitors are crucial for diabetes management, but invasive sampling, signal drift and frequent calibrations restrict their widespread usage. Microneedle sensors are emerging as a minimally-invasive platform for real-time monitoring of clinical parameters in interstitial fluid. Herein, a painless and flexible microneedle sensing patch is constructed by a mechanically-strong microneedle base and a thin layer of fluorescent hydrogel sensor for on-site, accurate, and continuous glucose monitoring. The Förster resonance energy transfer (FRET)-based hydrogel sensors are fabricated by facile photopolymerizations of acryloylated FRET pairs and glucose-specific phenylboronic acid. The optimized hydrogel sensor enables quantification of glucose with reversibility, high selectivity, and signal stability against photobleaching. Poly (ethylene glycol diacrylate)-co-polyacrylamide hydrogel is utilized as the microneedle base, facilitating effective skin piercing and biofluid extraction. The integrated microneedle sensor patch displays a sensitivity of 0.029 mM
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