神经母细胞瘤
肺癌
谱系（遗传）
癌症研究
生物
细胞谱系
细胞
计算生物学
细胞分化
遗传学
基因
医学
细胞培养
病理
作者
John B. Finlay,Abbie S. Ireland,Sarah B. Hawgood,Tony Reyes,Tiffany Ko,Rachelle R. Olsen,Ralph Abi Hachem,David W. Jang,Diana Bell,Joseph M. Chan,Bradley J. Goldstein,Trudy G. Oliver
出处
期刊：Cancer Cell
[Elsevier]
日期：2024-05-23
卷期号：42 (6): 1086-1105.e13
被引量：1
标识
DOI：10.1016/j.ccell.2024.05.003
摘要
The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse model of high-grade metastatic ONB exhibiting a NEUROD1
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