载脂蛋白B
胆固醇逆向转运
脂蛋白
临床试验
高密度脂蛋白
胆固醇
医学
生物信息学
胆固醇转移蛋白
功能(生物学)
计算生物学
内科学
生物
内分泌学
细胞生物学
作者
Shane R. Thomas,Yunjia Zhang,Kerry‐Anne Rye
标识
DOI:10.1016/j.beem.2022.101689
摘要
The high density lipoprotein (HDL) fraction of human plasma consists of multiple subpopulations of spherical particles that are structurally uniform, but heterogeneous in terms of size, composition and function. Numerous epidemiological studies have established that an elevated high density lipoprotein cholesterol (HDL-C) level is associated with decreased cardiovascular risk. However, with several recent randomised clinical trials of HDL-C raising agents failing to reduce cardiovascular events, contemporary research is transitioning towards clinical development of the cardioprotective functions of HDLs and the identification of functions that can be exploited for treatment of other diseases. This review describes the origins of HDLs and the causes of their compositional and functional heterogeneity. It then summarises current knowledge of how cardioprotective and other functions of HDLs are regulated. The final section of the review summarises recent advances in the clinical development of HDL-targeted therapies.
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