医学
胰腺导管腺癌
接收机工作特性
胰腺癌
阶段(地层学)
癌症
曲线下面积
内科学
人工智能
肿瘤科
机器学习
计算机科学
生物
古生物学
作者
Woohyung Lee,Hyo Jung Park,Hack‐Jin Lee,Eunsung Jun,Ki Byung Song,Dae Wook Hwang,Jae Hoon Lee,Kyongmook Lim,Namkug Kim,Seung Soo Lee,Jae Ho Byun,Hyoung Jung Kim,Song Cheol Kim
标识
DOI:10.1016/j.ijsu.2022.106851
摘要
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis even after curative resection. A deep learning-based stratification of postoperative survival in the preoperative setting may aid the treatment decisions for improving prognosis. This study was aimed to develop a deep learning model based on preoperative data for predicting postoperative survival.The patients who underwent surgery for PDAC between January 2014 and May 2015. Clinical data-based machine learning models and computed tomography (CT) data-based deep learning models were developed separately, and ensemble learning was utilized to combine two models. The primary outcomes were the prediction of 2-year overall survival (OS) and 1-year recurrence-free survival (RFS). The model's performance was measured by area under the receiver operating curve (AUC) and was compared with that of American Joint Committee on Cancer (AJCC) 8th stage.The median OS and RFS were 23 and 10 months in training dataset (n = 229), and 22 and 11 months in test dataset (n = 53), respectively. The AUC of the ensemble model for predicting 2-year OS and 1-year RFS in the test dataset was 0.76 and 0.74, respectively. The performance of the ensemble model was comparable to that of the AJCC in predicting 2-year OS (AUC, 0.67; P = 0.35) and superior to the AJCC in predicting 1-year RFS (AUC, 0.54; P = 0.049).Our ensemble model based on routine preoperative variables showed good performance for predicting prognosis for PDAC patients after surgery.
科研通智能强力驱动
Strongly Powered by AbleSci AI