化学
免疫疗法
PD-L1
癌症研究
癌症免疫疗法
免疫抑制
免疫检查点
铱
CD8型
肿瘤微环境
封锁
下调和上调
免疫系统
药理学
内科学
免疫学
医学
受体
生物化学
催化作用
基因
作者
Dongping Deng,Mengmeng Wang,Yan Su,Hongbao Fang,Yuncong Chen,Zhi Su
标识
DOI:10.1021/acs.jmedchem.4c00404
摘要
Anti-PD-L1 immunotherapy, a new lung cancer treatment, is limited to a few patients due to low PD-L1 expression and tumor immunosuppression. To address these challenges, the upregulation of PD-L1 has the potential to elevate the response rate and efficiency of anti-PD-L1 and alleviate the immunosuppression of the tumor microenvironment. Herein, we developed a novel usnic acid-derived Iridium(III) complex,
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