自噬
微泡
间充质干细胞
细胞凋亡
镉
毒物
DNA损伤
生殖细胞
细胞生物学
生物
程序性细胞死亡
再生(生物学)
癌症研究
化学
毒性
DNA
小RNA
遗传学
基因
有机化学
作者
Zhihong Chen,Jiahui Mo,Qiyun Yang,Zexin Guo,Xinyu Li,Dongmei Xie,Chunhua Deng
标识
DOI:10.1016/j.ecoenv.2024.116306
摘要
Cadmium, an environmental toxicant, severely impairs male reproductive functions and currently lacks effective clinical treatments. Mesenchymal stem cell-derived exosomes (MSC-Exos) are increasingly recognized as a potential alternative to whole-cell therapy for tissue injury and regeneration. This study aims to investigate the protective effects of MSC-Exos against cadmium toxicity on male reproduction. Our findings reveal that MSC-Exos treatment significantly promotes spermatogenesis, improves sperm quality, and reduces germ cell apoptosis in cadmium-exposed mice. Mechanistically, MSC-Exos dramatically mitigate cadmium-induced cell apoptosis in a spermatogonia cell line (GC-1 spg) in vitro by reducing DNA damage and promoting autophagic flux. These results suggest that MSC-Exos have a protective effect on cadmium-induced germ cell apoptosis by ameliorating DNA damage and autophagy flux, demonstrating the therapeutic potential of MSC-Exos for cadmium toxicity on male reproduction.
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