Could poor glycaemic control be a predictor of walking speed decline in older adults? Evidence from the English Longitudinal Study of Ageing

老化 最佳步行速度 糖尿病 老年学 纵向研究 老年人 糖化血红素 2型糖尿病 医学 人口学 物理疗法 内科学 内分泌学 病理 社会学
作者
Mariane Marques Luiz,Roberta de Oliveira Máximo,Dayane Capra de Oliveira,Paula Camila Ramírez,Aline Fernanda de Souza,Maicon Luís Bicigo Delinocente,Natália Cochar‐Soares,Andrew Steptoe,César de Oliveira,Tiago da Silva Alexandre
出处
期刊:Diabetes, Obesity and Metabolism [Wiley]
卷期号:26 (6): 2349-2358
标识
DOI:10.1111/dom.15549
摘要

Abstract Aim Although diabetes is a risk factor for walking speed decline in older adults, it remains unclear how glycaemic control [assessed by glycated haemoglobin (HbA1c)] might affect the long‐term trajectories of walking speed. We investigated whether the glycaemic control status accelerates the walking speed decline and whether this decline differs depending on previous mobility conditions. Materials and Methods In total, 3202 individuals aged ≥60 years from the English Longitudinal Study of Ageing (ELSA) were classified at baseline and after 4 and 8 years of follow‐up according to glycaemic control status as ‘without diabetes’ (no self‐reported diabetes and HbA1c <6.5%), ‘good glycaemic control’ (self‐reported diabetes and HbA1c ≥6.5% and <7.0%) and ‘poor glycaemic control’ (PGC) (self‐reported diabetes and HbA1c ≥7.0%). The generalized linear mixed models verified the walking speed trajectories in m/s. A second analysis was performed, including only participants without slowness at baseline (>0.8 m/s). Results Compared with the status ‘without diabetes’, the annual walking speed decline was −0.015 m/s for PGC and −0.011 m/s for good glycaemic control, totalling −0.160 and −0.130 m/s, respectively, over 8 years. Among those without slowness at baseline, only PGC had a significant walking speed decline, corresponding to −0.014 m/s per year and −0.222 m/s over 8 years. Conclusions Poor glycaemic control is a discriminator of walking speed decline in older adults, regardless of previous mobility conditions. It may serve as an early screening tool for those at risk of decreased functional performance later in life.
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