This research letter aims to contribute new critical understandings of the role of peer-to-peer collaborations and Open Innovation in fostering tourism ecosystems co-creation. By using the British Council – Innovation for African Universities project – Accelerating Youth Entrepreneurship and Innovation for Sustainable Tourism in Africa, as an illustrative case, it shares innovative practices. It calls for further research aimed at generating new theoretical and practical knowledge on tourism ecosystems, as a mechanism to enhance sector's sustainability and resilience and on the role of peer-to-peer collaborations and Indigenous Knowledge Systems informed OI, as enablers of tourism ecosystems to an develop innovative intervention, facilitate youth entrepreneurship, pivot market opportunities and advance strategies for a sustainable and resilient tourism sector in the long term.