抗菌剂
材料科学
败血症
肽
细菌
体内
巨噬细胞
微生物学
医学
免疫学
生物化学
生物
生物技术
体外
遗传学
作者
Zhizhen Meng,Luqi Pan,Songzan Qian,Xiao Yang,Lingling Pan,Runrun Chi,Jie Chen,Jingye Pan,Changcan Shi
标识
DOI:10.1016/j.matdes.2023.111883
摘要
Sepsis is a serious life-threatening disease. Bacterial infection is one of the main causes of sepsis. Although etiopathogenesis is gradually understood, the treatment is still scarce. Mortality caused by sepsis is still challenge. Herein, macrophage membrane coated antimicrobial peptide nanoparticles (M−AMPNP) was explored based on the specific binding of bacterial recognition receptors on macrophage membrane to bacteria. M−AMPNP was used to treat sepsis caused by bacterial infection. In vivo results showed that M−AMPNP was effectively delivered and retained at the site of infection by intravenous injection, which reduced the level of inflammatory factors and ultimately gave infected mice a significant survival advantage. M−AMPNP provides a potential strategy for targeted therapy of sepsis.
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