Long-term effect of styrene and ethylbenzene exposure on fasting plasma glucose: A gene-environment interaction study

乙苯 置信区间 内科学 医学 生物标志物 前瞻性队列研究 有害空气污染物 苯乙烯 2型糖尿病 糖尿病 内分泌学 化学 生物化学 污染物 聚合物 有机化学 共聚物 催化作用
作者
Linling Yu,Wei Liu,Min Zhou,Shijie Yang,Qiyou Tan,Lieyang Fan,Bin Wang,Weihong Chen
出处
期刊:Journal of Hazardous Materials [Elsevier BV]
卷期号:452: 131346-131346 被引量:7
标识
DOI:10.1016/j.jhazmat.2023.131346
摘要

Styrene and ethylbenzene (S/EB) are hazardous pollutants that have attracted worldwide concern. In this prospective cohort study, S/EB exposure biomarker (the sum of mandelic acid and phenylglyoxylic acid [MA+PGA]) and fasting plasma glucose (FPG) were repeatedly measured three times. The polygenic risk score (PRS) based on 137 single nucleotide polymorphisms for type 2 diabetes mellitus (T2DM) was calculated to evaluate cumulative genetic effect. In repeated-measures cross-sectional analyses, MA+PGA (β [95% confidence interval]: 0.106 [0.022, 0.189]) and PRS (0.111 [0.047, 0.176]) were significantly related to FPG. For long-term effect assessment, participants with sustained high MA+PGA or with high PRS had 0.021 (95% CI: −0.398, 0.441) or 0.465 (0.064, 0.866) mmol/L increase in FPG, respectively, over 3 years follow-up, and had 0.256 (0.017, 0.494) or 0.265 (0.004, 0.527) mmol/L increase in FPG, respectively, over 6 years follow-up. We further detected a significant interaction effect between MA+PGA and PRS on FPG change, compared with participants with sustained low MA+PGA and low PRS, those with sustained high MA+PGA and high PRS had 0.778 (0.319, 1.258) mmol/L increase in FPG (P for interaction=0.028) over 6 years follow-up. Our study provides the first evidence that long-term exposure to S/EB potentially increases FPG, which might be aggravated by genetic susceptibility.
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