黏膜黏附
口腔给药
生物利用度
药物输送
药品
剂型
鼻腔给药
色谱中的热响应聚合物
毒品携带者
药理学
材料科学
化学
纳米技术
色谱法
医学
高效液相色谱法
反相色谱法
作者
Kwadwo Mfoafo,Yadollah Omidi,Hossein Omidian
标识
DOI:10.1016/j.ijpharm.2023.122799
摘要
Thermoresponsive polymers have seen extensive use in the development of stimuli-responsive drug formulations for oral, buccal, nasal, ocular, topical, rectal, parenteral, and vaginal routes of administration. Despite their great potential, their use has been limited by various obstacles, such as undesirable high polymer concentration, wide gelation temperature, low gel strength, poor mucoadhesiveness, and short retention. Mucoadhesive polymers have been suggested to improve the mucoadhesive features of thermoresponsive gels, leading to increased drug bioavailability and efficacy. This article highlights the use of in-situ thermoresponsive mucoadhesive hydrogel blends or hybrids that have been developed and assessed in various routes of administration.
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