曲线下面积
医学
曲线下面积
生物标志物
内科学
实时聚合酶链反应
计算机辅助设计
心脏病学
胃肠病学
冠状动脉疾病
小RNA
接收机工作特性
诊断生物标志物
肿瘤科
生物
基因
遗传学
药代动力学
生物化学
作者
Xiaodong Pan,Yanru He,Sunkai Ling,Zhongpu Chen,Gaoliang Yan
出处
期刊:Clinical Laboratory
[Clinical Laboratory Publications]
日期:2020-01-01
卷期号:66 (08/2020)
被引量:2
标识
DOI:10.7754/clin.lab.2020.191138
摘要
The present study aimed to explore the diagnostic value of miR-15a in coronary artery disease (CAD).After recruiting all the participants, peripheral blood samples were obtained according to the instructions. miR-15a expression was evaluated using real-time quantitative polymerase chain reaction (RT-qPCR) and IL-6, TNF-α, and hs-CRP expressions were detected using ELISA kits.The results elucidated a significantly decreased expression of miR-15a in peripheral blood samples from CAD patients compared to non-CAD controls (p < 0.01). Meanwhile, miR-15a expression was negatively correlated with LDL-C and Gensini score (p = 0.0059, 0.0243, respectively). Moreover, miR-15a expression was negatively correlated with inflammatory cytokines IL-6, TNF-α, and hs-CRP (p = 0.0009, 0.0178, 0.0005, respectively). The receiver operating curve (ROC) curve analysis demonstrated that miR-15a was a promising biomarker for early diagnosis of CAD with an area under the curve (AUC) of 0.9368.The present study elucidated a decreased miR-15a expression in CAD patients and showed negative correlations with LDL-C, Gensini score, and inflammatory cytokines. miR-15a may serve as a promising biomarker for early diagnosis of CAD.
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