Certolizumab pegol for the treatment of psoriatic arthritis and plaque psoriasis

医学 妥珠单抗 银屑病性关节炎 指炎 银屑病 末端炎 依那西普 临床试验 皮肤病科 内科学 类风湿性关节炎
作者
Maria Esposito,Francesco Carubbi,Alessandro Giunta,Alessia Alunno,Roberto Giacomelli,Maria Concetta Fargnoli
出处
期刊:Expert Review of Clinical Immunology [Informa]
卷期号:16 (2): 119-128 被引量:12
标识
DOI:10.1080/1744666x.2020.1713754
摘要

Introduction: Certolizumab pegol (CZP) is an Fc-free PEGylated TNF-α inhibitor approved for the treatment of psoriatic arthritis (PsA) and plaque psoriasis in many countries. It demonstrated favorable results in PsA in terms of improvement in peripheral arthritis, dactylitis, and enthesitis in a phase III trial (RAPID-PSA) and in real-life experiences. Recently, three phase III randomized clinical trials (CIMPASI-1, CIMPASI-2, CIMPACT) showed significant and sustained improvements in signs and symptoms of moderate-to-severe plaque psoriasis as well as in quality of life parameters as compared to placebo and etanercept.Areas covered: We reviewed the structure and the mechanism of action of CZP, and critically analyzed data from clinical trials and real-life, concerning its efficacy and safety in all aspects of the psoriatic disease. We designed a comprehensive literature search on this topic, by a review of published articles in indexed international journals up until 31 July 2019.Expert opinion: CZP demonstrated positive results in several domains of psoriatic disease, also in patients previously exposed to other TNF-α inhibitors and in patients receiving re-treatment after treatment interruption. The peculiar chemical structure, along with its well-established efficacy and safety, support CZP as the drug of choice in specific subgroups of patients with psoriatic disease, in particular patients with comorbidities and pregnant or breastfeeding female patients.
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