内分泌学
内科学
重吸收
多尿
多饮
糖异生
化学
肾葡萄糖重吸收
肾
糖尿病
水通道蛋白2
医学
新陈代谢
2型糖尿病
机械工程
工程类
入口
水道
作者
Guangshan Zhao,Ximing Wu,Wenping Wang,Chung S. Yang,Jinsong Zhang
标识
DOI:10.1002/mnfr.202000505
摘要
Abstract Scope: Tea, made from the plant Camellia sinensis , is known to have anti‐diabetes effects and different mechanisms of action are proposed. Kidney is a vital organ in managing water reabsorption and glucose metabolism, and is greatly influenced by diabetes. The present study investigates the effects of tea administration on water reabsorption and gluconeogenesis in the kidney of diabetic mice. Methods and results: Db/db mice are given tea infusion as drinking fluid when they begin to exhibit hyperglycemia. It is found that green tea or black tea infusion potently elevates renal proteins vital for water reabsorption, including protein kinase C‐α, aquaporin 2, and urea transporter‐A1, as well as increases trafficking of these proteins to apical plasma membrane where they exert water reabsorption function. The treatment also downregulates renal gluconeogenic enzymes, including glucose‐6‐phosphatase‐α and phosphoenolpyruvate carboxykinase. Associated with these biochemical changes are the rectified polyuria, polydipsia, polyphagia, and hyperglycemia, all symptoms of diabetes. Conclusions: For the first time, the present study demonstrates that tea has robust effects in enhancing kidney water reabsorption proteins and downregulating gluconeogenic enzymes in db/db mice. It remains to be investigated whether such beneficial effects of tea occur in humans.
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