Associations of Adiposity, Circulating Protein Biomarkers, and Risk of Major Vascular Diseases

医学 孟德尔随机化 内科学 体质指数 肥胖 比例危险模型 肿瘤科 内分泌学 基因型 遗传学 生物 基因 遗传变异
作者
Yuanjie Pang,Christiana Kartsonaki,Jun Lv,Zammy Fairhurst-Hunter,Iona Y. Millwood,Canqing Yu,Yu Guo,Yiping Chen,Bin Zheng,Ling Yang,Junshi Chen,Robert Clarke,Robin Walters,Michael V. Holmes,Liming Li,Zhengming Chen
出处
期刊:JAMA Cardiology [American Medical Association]
卷期号:6 (3): 276-276 被引量:38
标识
DOI:10.1001/jamacardio.2020.6041
摘要

Obesity is associated with a higher risk of cardiovascular disease (CVD), but little is known about the role that circulating protein biomarkers play in this association.To examine the observational and genetic associations of adiposity with circulating protein biomarkers and the observational associations of proteins with incident CVD.This subcohort study included 628 participants from the prospective China Kadoorie Biobank who did not have a history of cancer at baseline. The Olink platform measured 92 protein markers in baseline plasma samples. Data were collected from June 2004 to January 2016 and analyzed from January 2019 to June 2020.Measured body mass index (BMI) obtained during the baseline survey and genetically instrumented BMI derived using 571 externally weighted single-nucleotide variants.Cross-sectional associations of adiposity with biomarkers were examined using linear regression. Associations of biomarkers with CVD risk were assessed using Cox regression among those without prior cancer or CVD at baseline. Mendelian randomization was conducted to derive genetically estimated associations of BMI with biomarkers.In observational analyses of 628 individuals (mean [SD] age, 52.2 [10.5] years; 385 women [61.3%]), BMI (mean [SD], 23.9 [3.6]) was positively associated with 27 proteins (per 1-SD higher BMI; eg, interleukin-6: 0.21 [95% CI, 0.12-0.29] SD; interleukin-18: 0.13 [95% CI, 0.05-0.21] SD; monocyte chemoattractant protein-1: 0.12 [95% CI, 0.04-0.20] SD; hepatocyte growth factor: 0.31 [95% CI, 0.24-0.39] SD), and inversely with 3 proteins (Fas ligand: -0.11 [95% CI, -0.19 to -0.03] SD; TNF-related weak inducer of apoptosis, -0.14 [95% CI, -0.23 to -0.06] SD; and carbonic anhydrase 9: (-0.14 [95% CI, -0.22 to -0.05] SD), with similar associations identified for other adiposity traits (eg, waist circumference [r = 0.96]). In mendelian randomization, the associations of genetically elevated BMI with specific proteins were directionally consistent with the observational associations. In meta-analyses of genetically elevated BMI with 8 proteins, combining present estimates with previous studies, the most robust associations were shown for interleukin-6 (per 1-SD higher BMI; 0.21 [95% CI, 0.13-0.29] SD), interleukin-18 (0.16 [95% CI, 0.06-0.26] SD), monocyte chemoattractant protein-1 (0.21 [95% CI, 0.11-0.30] SD), monocyte chemotactic protein-3 (0.12 [95% CI, 0.03-0.21] SD), TNF-related apoptosis-inducing ligand (0.23 [95% CI, 0.13-0.32] SD), and hepatocyte growth factor (0.14 [95% CI, 0.06-0.22] SD). Of the 30 BMI-associated biomarkers, 10 (including interleukin-6, interleukin-18, and hepatocyte growth factor) were nominally associated with incident CVD.Mendelian randomization shows adiposity to be associated with a range of protein biomarkers, with some biomarkers also showing association with CVD risk. Future studies are warranted to validate these findings and assess whether proteins may be mediators between adiposity and CVD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
往前冲完成签到,获得积分10
1秒前
卡拉米完成签到,获得积分10
2秒前
2秒前
kitty发布了新的文献求助10
2秒前
罗rr完成签到 ,获得积分10
3秒前
23xyke完成签到,获得积分10
3秒前
wwewew完成签到,获得积分10
3秒前
知性的紫寒完成签到 ,获得积分10
3秒前
3秒前
wzxhhh完成签到,获得积分10
3秒前
橙子完成签到 ,获得积分10
4秒前
江宜完成签到 ,获得积分10
5秒前
6秒前
微风打了烊完成签到 ,获得积分10
6秒前
exquisite完成签到,获得积分10
7秒前
crisis发布了新的文献求助10
7秒前
Deseorz完成签到,获得积分20
7秒前
风181013发布了新的文献求助10
8秒前
123完成签到,获得积分10
8秒前
smmu008完成签到,获得积分10
8秒前
8秒前
8秒前
CipherSage应助土拨鼠采纳,获得10
9秒前
冥冥之极为昭昭应助ayayaya采纳,获得10
9秒前
彤光赫显完成签到,获得积分10
10秒前
10秒前
rrrrroxie完成签到,获得积分10
10秒前
打打应助Shandongdaxiu采纳,获得10
12秒前
枫凝静影发布了新的文献求助10
12秒前
12秒前
曾珍完成签到 ,获得积分10
13秒前
Jiang发布了新的文献求助10
14秒前
朴实的草丛完成签到 ,获得积分10
14秒前
14秒前
徐志成完成签到 ,获得积分10
15秒前
15秒前
15秒前
kk完成签到,获得积分10
15秒前
李健应助Demon采纳,获得10
16秒前
尔玉完成签到 ,获得积分10
16秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4009325
求助须知:如何正确求助?哪些是违规求助? 3549162
关于积分的说明 11301105
捐赠科研通 3283572
什么是DOI,文献DOI怎么找? 1810370
邀请新用户注册赠送积分活动 886205
科研通“疑难数据库(出版商)”最低求助积分说明 811301