七氟醚
地氟醚
麻醉
丘脑底核
帕金森病
脑深部刺激
医学
神经生理学
全身麻醉
最低肺泡浓度
内科学
心理学
神经科学
疾病
作者
Yu‐Chen Chen,Shin-Yuan Chen,Tsung‐Ying Chen,Jen-Wei Pan,Sheng‐Tzung Tsai
标识
DOI:10.1016/j.bja.2020.09.041
摘要
BackgroundDesflurane and sevoflurane are commonly used during inhalational anaesthesia, but few studies have investigated their effects on deep cerebral neuronal activity. In addition, the association between subthalamic nucleus (STN) neurophysiology and general anaesthesia induced by volatile anaesthetics are not yet identified. This study aimed to identify differences in neurophysiological characteristics of the STN during comparable minimal alveolar concentration (MAC) desflurane and sevoflurane anaesthesia for deep brain stimulation (DBS) in patients with Parkinson's disease.MethodsTwelve patients with similar Parkinson's disease severity received desflurane (n=6) or sevoflurane (n=6) during DBS surgery. We obtained STN spike firing using microelectrode recording at 0.5–0.6 MAC and compared firing rate, power spectral density, and coherence.ResultsNeuronal firing rate was lower with desflurane (47.4 [26.7] Hz) than with sevoflurane (63.9 [36.5] Hz) anaesthesia (P<0.001). Sevoflurane entrained greater gamma oscillation power than desflurane (62.9% [0.9%] vs 57.0% [1.5%], respectively; P=0.002). There was greater coherence in the theta band of the desflurane group compared with the sevoflurane group (13% vs 6%, respectively). Anaesthetic choice did not differentially influence STN mapping accuracy or the clinical outcome of DBS electrode implantation.ConclusionsDesflurane and sevoflurane produced distinct neurophysiological profiles in humans that may be associated with their analgesic and hypnotic actions.
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