已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Making drugs out of sunlight and ‘thin air’: an emerging synergy of synthetic biology and natural product chemistry

天然产物 药物发现 合成生物学 计算生物学 萜烯 生物 生化工程 生物技术 生物信息学 工程类 生物化学
作者
Michael J. Stephenson,Anne Osbourn
出处
期刊:The biochemist [Portland Press]
卷期号:42 (4): 34-39 被引量:1
标识
DOI:10.1042/bio20200044
摘要

Nature has long served as a rich source of structurally diverse small organic molecules with medicinally relevant biological activities. Despite the historical success of these so-called natural products, the enthusiasm of big pharma to explore these compounds as leads in drug design has waxed and waned. A major contributor to this is their often inherent structural complexity. Such compounds are difficult (often impossible) to access synthetically, a hurdle that can stifle lead development and hinder sustainable large-scale production of promising leads for clinical evaluation. However, in recent years, an emerging synergy between synthetic biology and natural product chemistry offers the potential for a renaissance in our ability to access natural products for drug discovery and development. Advances in genome sequencing, bioinformatics and the maturing of heterologous expression platforms are increasing, enabling the study, and ultimately, the manipulation of plant biosynthetic pathways. The triterpenes are one of the most structurally diverse families of natural products and arguably one of the most underrepresented in the clinic. The plant kingdom is the richest source of triterpene diversity, with >20,000 triterpenes reported so far. Transient expression of genes for candidate enzymes and pathways in amenable plant species is emerging as a powerful and rapid means of investigating and harnessing the plant enzymes involved in generating this diversity. Such platforms also have the potential to serve as production systems in their own right, with the possibility of upscaling these discoveries into commercially useful products using the same overall basic procedure. Ultimately, the carbon source for generation of high-value compounds in plants is photosynthesis. Therefore, we could, with the help of plants, be producing new medicines out of sunlight and ‘thin air’ in green factories in the not too distant future.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
周mm发布了新的文献求助10
2秒前
陈静完成签到,获得积分10
5秒前
卷123完成签到,获得积分10
7秒前
Huay完成签到 ,获得积分10
8秒前
daizao完成签到,获得积分10
9秒前
慕青应助End采纳,获得10
9秒前
勤恳化蛹完成签到 ,获得积分10
10秒前
11秒前
bing完成签到 ,获得积分10
15秒前
周mm完成签到,获得积分10
16秒前
16秒前
传奇3应助daizao采纳,获得10
17秒前
上官若男应助中中采纳,获得10
18秒前
原始动物研究者协会完成签到 ,获得积分10
18秒前
红枫没有微雨怜完成签到 ,获得积分10
18秒前
顾矜应助liu采纳,获得10
19秒前
典雅葶完成签到 ,获得积分10
21秒前
21秒前
陈静发布了新的文献求助10
21秒前
yyymmma应助__采纳,获得10
23秒前
24秒前
风止完成签到,获得积分10
24秒前
24秒前
End完成签到,获得积分20
26秒前
现代小笼包完成签到,获得积分10
27秒前
27秒前
End发布了新的文献求助10
29秒前
32秒前
CcXiXi完成签到 ,获得积分10
33秒前
科研通AI2S应助End采纳,获得10
33秒前
谁猪沉浮完成签到,获得积分10
34秒前
37秒前
msk完成签到,获得积分10
37秒前
39秒前
Ken完成签到,获得积分10
39秒前
B612小行星完成签到 ,获得积分10
41秒前
小蘑菇应助紫荆采纳,获得10
44秒前
科研通AI2S应助科研通管家采纳,获得30
46秒前
爱静静应助科研通管家采纳,获得10
47秒前
Orange应助科研通管家采纳,获得10
47秒前
高分求助中
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
麻省总医院内科手册(原著第8版) (美)马克S.萨巴蒂尼 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
宽禁带半导体紫外光电探测器 388
COSMETIC DERMATOLOGY & SKINCARE PRACTICE 388
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3142628
求助须知:如何正确求助?哪些是违规求助? 2793439
关于积分的说明 7806660
捐赠科研通 2449725
什么是DOI,文献DOI怎么找? 1303403
科研通“疑难数据库(出版商)”最低求助积分说明 626861
版权声明 601309