DEVELOPMENT OF COPROCESSED EXCIPIENTS OF XANTHAN GUM AND ACACIA GUM AS A CONTROLLED RELEASE MATRIX FOR FAMOTIDINE FLOATING TABLETS

黄原胶 法莫替丁 阿拉伯树胶 赋形剂 色谱法 化学 基质(化学分析) 天然口香糖 多糖 材料科学 流变学 食品科学 有机化学 药理学 复合材料 医学
作者
Unsyura Dhipa Budaya,Silvia Surini
出处
期刊:International Journal of Applied Pharmaceutics [Innovare Academic Sciences]
卷期号:: 192-196 被引量:4
标识
DOI:10.22159/ijap.2020.v12s1.ff044
摘要

Objective: Controlled release floating tablets require excipients, which act as a matrix to control the release of the active drug and facilitatethe tablet floating in the gastric milieu. One potential excipient is coprocessed excipients of xanthan gum and acacia gum (Co-XG-GA), which isa physical modification of the two natural polymers. In this study, we produced several Co-XG-GA and used them as matrices in floating tabletformulations.Methods: Several coprocessed excipients were prepared from xanthan gum and acacia gum at ratios of 1:1, 1:2, 2:1, 1:3, and 3:1. The obtainedexcipients were then characterized physically, chemically, and functionally. The coprocessed excipients were then formulated in floating tablets usingfamotidine as the drug model. The floating tablets were then evaluated in terms of the tablet floating capabilities and the drug release in HCl mediumat pH 1.2 for 8 h.Results: Our results showed that the coprocessed excipients were a fine powder, odorless, and a grayish-white color. The excipients had a goodswelling index, fairly large viscosity, and good gel strength; hence, they were suitable to be applied as the matrices of floating tablet formulations. Thefloating tablets of F2, which contained the Co-XG-GA 1:2, demonstrated the best characteristics with 8.33±0.58 min of floating lag time and 24 h oftotal floating time. Further release studies revealed that the famotidine floating tablets, which used Co-XG-GA (F1–F5) as matrices, controlled drugrelease with zero-order release kinetics and could be used for controlled release dosage forms.Conclusion: Collectively, our results indicate that the Co-XG-GA can be applied as matrices in controlled release floating tablets
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