神经科学
5-羟色胺能
前脑
缰
心理学
疾病
多巴胺能
多巴胺能途径
帕金森病
生物神经网络
萧条(经济学)
基底神经节
医学
多巴胺
中枢神经系统
血清素
内科学
病理
经济
受体
宏观经济学
作者
Hailan Hu,Yihui Cui,Yan Yang
标识
DOI:10.1038/s41583-020-0292-4
摘要
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb) owing to new discoveries relating to its critical role in regulating negatively motivated behaviour and its implication in major depression. The LHb, sometimes referred to as the brain's 'antireward centre', receives inputs from diverse limbic forebrain and basal ganglia structures, and targets essentially all midbrain neuromodulatory systems, including the noradrenergic, serotonergic and dopaminergic systems. Its unique anatomical position enables the LHb to act as a hub that integrates value-based, sensory and experience-dependent information to regulate various motivational, cognitive and motor processes. Dysfunction of the LHb may contribute to the pathophysiology of several psychiatric disorders, especially major depression. Recently, exciting progress has been made in identifying the molecular and cellular mechanisms in the LHb that underlie negative emotional state in animal models of drug withdrawal and major depression. A future challenge is to translate these advances into effective clinical treatments.
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