血管生成
医学
传统医学
中医药
缺血性中风
临床试验
药理学
新生血管
替代医学
内科学
病理
缺血
作者
Lan Bu,Ou Dai,Fei Zhou,Fei Liu,Jinfeng Chen,Cheng Peng,Liang Xiong
标识
DOI:10.1016/j.biopha.2020.110855
摘要
Ischemic diseases, such as ischemic heart diseases and ischemic stroke, are the leading cause of death worldwide. Angiogenic therapy is a wide-ranging approach to fighting ischemic diseases. However, compared with anti-angiogenesis therapy for tumors, less attention has been paid to therapeutic angiogenesis. Recently, Traditional Chinese medicine (TCM) has garnered increasing interest for its definite curative effect and low toxicity. A growing number of studies have reported that TCM formulas, extracts, and compounds from herbal medicines exert pro-angiogenic activity, which has been confirmed in a few clinical trials. For comprehensive analysis of relevant literature, global and local databases including PubMed, Web of Science, and China National Knowledge Infrastructure were searched using keywords such as “angiogenesis,” “neovascularization,” “traditional Chinese medicine,” “formula,” “extract,” and “compound.” Articles were chosen that are closely and directly related to pro-angiogenesis. This review summarizes the pro-angiogenic activity and the mechanism of TCM formulas, extracts, and compounds; it delivers an in-depth understanding of the relationship between TCM and pro-angiogenesis and will provide new ideas for clinical practice.
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