结核分枝杆菌
磷酸蛋白质组学
肺结核
病菌
生物
蛋白质组
毒力
寄主(生物学)
蛋白质组学
计算生物学
免疫系统
宿主-病原体相互作用
微生物学
磷酸化
蛋白质磷酸化
免疫学
生物信息学
遗传学
医学
基因
蛋白激酶A
病理
作者
Zilu Wang,Jianping Xie
标识
DOI:10.1016/j.cellsig.2021.110238
摘要
Tuberculosis caused by Mycobacterium tuberculosis (Mtb) remains a tremendous global public health concern. Deciphering the biology of the pathogen and its interaction with host can inspire new measures against tuberculosis. Phosphorylation plays versatile and important role in the pathogen and host physiology, such as virulence, signaling and immune response. Proteome-wide phosphorylation of Mtb and its infected host cells, namely phosphoproteome, can inform the post-translational modification of the interaction network between the pathogen and the host, key targets for novel antibiotics. We summarized the phosphoproteome of Mtb, as well as the host, focusing on potential application for new measures against tuberculosis.
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