An ultra-compact and wireless tag for battery-free sweat glucose monitoring

检出限 材料科学 可穿戴计算机 光电子学 无线 足迹 天线(收音机) 计算机科学 生物医学工程 化学 嵌入式系统 电信 医学 古生物学 色谱法 生物
作者
Hadi Mirzajani,Taher Abbasiasl,Fariborz Mirlou,Emin Istif,Mohammad Javad Bathaei,Çağdaş Dağ,Oğuzhan Deyneli,Dilek Yazıcı,Levent Beker
出处
期刊:Biosensors and Bioelectronics [Elsevier BV]
卷期号:213: 114450-114450 被引量:22
标识
DOI:10.1016/j.bios.2022.114450
摘要

Glucose monitoring before, during, and after exercise is essential for people with diabetes as exercise increases the risk of activity-induced hyper- and hypo-glycemic events. The situation is even more challenging for athletes with diabetes as they have impaired metabolic control compared to sedentary individuals. In this regard, a compact and noninvasive wearable glucose monitoring device that can be easily worn is critical to enabling glucose monitoring. This report presents an ultra-compact glucose tag with a footprint and weight of 1.2 cm2 and 0.13 g, respectively, for sweat analysis. The device comprises a near field communication (NFC) chip, antenna, electrochemical sensor, and microfluidic channels implemented in different material layers. The device has a flexible and conformal structure and can be easily attached to different body parts. The battery-less operation of the device was enabled by NFC-based wireless power transmission and the compact antenna. Femtosecond laser ablation was employed to fabricate a highly compact and flexible NFC antenna. The proposed device demonstrated excellent operating characteristics with a limit of detection (LOD), limit of quantification (LOQ), and sensitivity of 24 μM, 74 μM, and 1.27 μA cm-2 mM-1, respectively. The response of the proposed sensor in sweat glucose detection and quantification was validated by nuclear magnetic resonance spectroscopy (NMR). Also, the device's capability in attachment to the body, sweat collection, and glucose measurement was demonstrated through in vitro and in vivo experiments, and satisfactory results were obtained.
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