Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection

甘胆酸 牛磺胆酸 六烯酸 代谢物 胆酸 亚油酸 胆汁酸 生物 医学 生物化学 脂肪酸 多不饱和脂肪酸
作者
Jian Wu,Yanping Xu,Yubao Cui,Mariza Bortolanza,Minjie Wang,Bin Jiang,Meina Yan,Wei Liang,Yiwen Yao,Qiaoling Pan,Jinfeng Yang,Jiong Yu,Dawei Wang,Hongcui Cao,Lanjuan Li
出处
期刊:Journal of Medical Virology [Wiley]
卷期号:94 (6): 2714-2726 被引量:12
标识
DOI:10.1002/jmv.27669
摘要

Dynamic changes in metabolites may affect liver disease progression, and provide new methods for predicting liver damage. We used ultra-performance liquid chromatography-mass spectroscopy to assess serum metabolites in healthy controls (HC), and patients with acute hepatitis E (AHE) or hepatitis E virus acute liver failure (HEV-ALF). The principal component analysis, partial least squares discriminant analysis, and discriminant analysis of orthogonal projections to latent structures models illustrated significant differences in the metabolite components between AHE patients and HCs, or between HEV-ALF and AHE patients. In pathway enrichment analysis, we further identified two altered pathways, including linoleic acid metabolism and phenylalanine, tyrosine, and tryptophan biosynthesis, when comparing AHE patients with HCs. Linoleic acid metabolism and porphyrin and chlorophyll metabolism pathways were significantly different in HEV-ALF when compared with AHE patients. The discriminative performances of differential metabolites showed that taurocholic acid, glycocholic acid, glycochenodeoxycholate-3-sulfate, and docosahexaenoic acid could be used to distinguish HEV-ALF from AHE patients. The serum levels of glycocholic acid, taurocholic acid, deoxycholic acid glycine conjugate, and docosahexaenoic acid were associated with the prognosis of HEV-ALF patients. Dynamic changes in serum metabolites were associated with AHE infection and severity. The identified metabolites can be used to diagnose and predict the prognosis of HEV-ALF.
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