巴科帕蒙尼里酒店
神经保护
黑质
致密部
帕金森病
多巴胺能
医学
神经炎症
氧化应激
多巴胺
药理学
神经科学
疾病
生物
内科学
作者
Ahsas Goyal,Sainu Gopika,Abhishek Kumar,Debapriya Garabadu
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2022-03-17
卷期号:23 (9): 889-901
被引量:8
标识
DOI:10.2174/1389450123666220316091734
摘要
Abstract: Parkinson's disease is a chronic and gradually progressive neurodegenerative disorder trig-gered due to the loss of dopamine-releasing neurons in the region of substantia nigra pars compacta characterized by the motor symptoms, such as tremor, bradykinesia, akinesia, and postural instability. Proteinopathies, mitochondrial dysfunction induced dopaminergic neuronal deterioration, and gene mutations are the hallmarks of Parkinson's disease. The bioactive components of Brahmi, such as Bacoside A, Bacoside B, and Bacosaponins, belong to various chemical families. Brahmi's neuropro-tective role includes reducing neuronal oxidative stress, dopaminergic neuronal degeneration, mito-chondrial dysfunction, inflammation, inhibition of α-synuclein aggregation, and improvement of cog-nitive and learning behaviour. Researchers found that Bacopa monnieri significantly increased brain levels of glutathione, vitamin C, vitamin E, and vitamin A in rats exposed to cigarette smoke. Brahmi has a potent antioxidant property and neuroprotective effects against PD that help reduce oxidative stress and neuroinflammation and enhance dopamine levels. The review collates all the preclinical studies that prove the beneficial neuroprotective effect of Brahmi for treating PD.
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