光热治疗
体内
光动力疗法
癌症
癌细胞
细胞毒性
材料科学
纳米技术
癌症治疗
癌症治疗
化学
癌症研究
体外
生物
生物化学
生物技术
有机化学
遗传学
作者
Hao Zhao,Yuduo Guo,Anran Yuan,Shengpeng Xia,Zhiqiang Gao,Yiming Huang,Fengting Lv,Libing Liu,Shu Wang
标识
DOI:10.1007/s40843-021-2003-5
摘要
Multimodal therapy has been recognized as a powerful platform for the precise treatment of cancer. However, the reported multimodal therapeutic systems often involve sophisticated components and tedious fabrication procedures. As such, developing nature-inspired and easily-obtainable theranostic agents for multimodal cancer therapy remains challenging. In this work, we propose nature-inspired nanothylakoids as a multimodal theranostic agent for cancer therapy both in vitro and in vivo. Nanothylakoids extracted from spinach leaves exhibit prominent photothermal and photodynamic inactivation on 4T1 and MCF-7 cancer cells due to their outstanding photothermal conversion/photosensitization capabilities. Additionally, the peroxidase-like catalytic activity of nanothylakoids is simultaneously verified, which facilitates the oxidation of H2O2 to the cytotoxic hydroxyl radical (·OH) and thus cause efficient cell apoptosis. Interestingly, a selective cytotoxicity of nanothylakoids on MCF-7 cancer cells is found due to their overexpression of H2O2. In vitro and in vivo results substantiate the prominent therapeutic outcome and excellent biosafety of nanothylakoids. Nanothylakoids with photothermal/photodynamic effects and peroxidase-like catalytic activity open a new avenue for the development of nature-inspired theranostic materials, holding great promise in multimodal cancer therapeutics.
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