亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Rules of Chinese Herbal Intervention of Radiation Pneumonia Based on Network Pharmacology and Data Mining

中医药 药物数据库 传统医学 药理学 自动停靠 系统药理学 草本植物 计算生物学 医学 化学 生物 草药 生物化学 基因 病理 替代医学 生物信息学 药品
作者
Wenchao Dan,Cong Wu,Chunyan Xue,Jinlei Liu,Xinyuan Guo,Yanjie Lian
出处
期刊:Evidence-based Complementary and Alternative Medicine [Hindawi Limited]
卷期号:2022: 1-13 被引量:8
标识
DOI:10.1155/2022/7313864
摘要

Objective. To explore the mechanism and principles of traditional Chinese medicine (TCM) in the management of radiation pneumonia. Methods. The targets of radiation pneumonia were obtained by screening the GeneCards, OMIM, TTD, DrugBank, and HERB databases, analyzing ADME parameters. In addition, compounds and Chinese herbs that can act on the targets were screened from the TCMSP database. The core target compounds for TCM were used to construct the target-compound, compound-traditional Chinese medicine, and target-compound-traditional Chinese medicine networks. These networks were further used to select the core targets, compounds, and TCM. The binding strength between the core targets and compounds was determined using AutoDock Vina. The trajectory for the molecular dynamics simulation was completed by Desmond version 2020. Results. A total of 55 active targets in radiation pneumonia were identified. Subsequently, 137 candidate compounds and 469 Chinese herbs were matched. Frequency statistics showed that the Chinese herbs that could interfere with radiation pneumonia were mainly bitter, spicy, and sweet, with both cold and warm properties. Moreover, they mainly belonged to liver and lung channels. The core targets included TNF, IL-6, TGF-β1, and TP53. The most important components were quercetin, resveratrol, and (-)-epigallocatechin-3-gallate. Moreover, the most significant traditional Chinese herbs were Perilla pueraria, ephedra, Lonicerae japonicae, and sea buckthorn. Furthermore, analysis of 222 sets of receptor-ligand docking results suggested that the compounds had good docking activity to their core targets. By combining the docking binding energy, we determined that the chemical compounds had strong binding energy to the targets. Conclusion. Using network pharmacology, we explored the potential mechanism of TCM in the treatment of radiation pneumonia. The general rules for application of TCM in the treatment of radiation pneumonia were summarized. This study provides baseline information for future research on the development of TCM for the management of radiation pneumonia.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI

祝大家在新的一年里科研腾飞
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
辣椒完成签到 ,获得积分10
6秒前
19秒前
20秒前
xbbccc完成签到,获得积分10
32秒前
上官若男应助snsut采纳,获得10
33秒前
33完成签到,获得积分0
35秒前
snsut完成签到,获得积分10
44秒前
科研通AI2S应助科研通管家采纳,获得10
49秒前
科研通AI2S应助科研通管家采纳,获得10
49秒前
华仔应助科研通管家采纳,获得30
49秒前
49秒前
1分钟前
1分钟前
sangsang完成签到,获得积分10
2分钟前
勤恳的断秋完成签到 ,获得积分10
2分钟前
sangsang发布了新的文献求助10
2分钟前
zotero完成签到,获得积分20
2分钟前
2分钟前
2分钟前
zotero发布了新的文献求助30
2分钟前
顾矜应助Mr.Sui采纳,获得10
2分钟前
2分钟前
小李完成签到,获得积分10
2分钟前
2分钟前
zkexuan完成签到,获得积分10
2分钟前
2分钟前
2分钟前
科研通AI2S应助sangsang采纳,获得10
2分钟前
激动的似狮完成签到,获得积分10
2分钟前
2分钟前
Mr.Sui发布了新的文献求助10
2分钟前
hxw发布了新的文献求助10
2分钟前
2分钟前
Iris发布了新的文献求助10
2分钟前
Mr.Sui完成签到,获得积分10
2分钟前
3分钟前
3分钟前
22发布了新的文献求助10
3分钟前
3分钟前
4分钟前
高分求助中
Востребованный временем 2500
The Three Stars Each: The Astrolabes and Related Texts 1500
Classics in Total Synthesis IV: New Targets, Strategies, Methods 1000
Les Mantodea de Guyane 800
Mantids of the euro-mediterranean area 700
The Oxford Handbook of Educational Psychology 600
有EBL数据库的大佬进 Matrix Mathematics 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 内科学 物理 纳米技术 计算机科学 遗传学 化学工程 基因 复合材料 免疫学 物理化学 细胞生物学 催化作用 病理
热门帖子
关注 科研通微信公众号,转发送积分 3413375
求助须知:如何正确求助?哪些是违规求助? 3015679
关于积分的说明 8871627
捐赠科研通 2703387
什么是DOI,文献DOI怎么找? 1482240
科研通“疑难数据库(出版商)”最低求助积分说明 685170
邀请新用户注册赠送积分活动 679951