疾病
蛋白质组
肾脏疾病
生物
人口
数量性状位点
表达数量性状基因座
遗传学
遗传建筑学
遗传变异
基因
医学
基因型
单核苷酸多态性
病理
内分泌学
环境卫生
作者
Aditya Surapaneni,Pascal Schlosser,Linda Zhou,Celina Liu,Nilanjan Chatterjee,Dan E. Arking,Diptavo Dutta,Josef Coresh,Eugene P. Rhee,Morgan E. Grams
标识
DOI:10.1016/j.kint.2022.07.005
摘要
Investigations into the causal underpinnings of disease processes can be aided by the incorporation of genetic information. Genetic studies require populations varied in both ancestry and prevalent disease in order to optimize discovery and ensure generalizability of findings to the global population. Here, we report the genetic determinants of the serum proteome in 466 African Americans with chronic kidney disease attributed to hypertension from the richly phenotyped African American Study of Kidney Disease and Hypertension (AASK) study. Using the largest aptamer-based protein profiling platform to date (6,790 proteins or protein complexes), we identified 969 genetic associations with 900 unique proteins; including 52 novel cis (local) associations and 379 novel trans (distant) associations. The genetic effects of previously published cis-protein quantitative trait loci (pQTLs) were found to be highly reproducible, and we found evidence that our novel genetic signals colocalize with gene expression and disease processes. Many trans- pQTLs were found to reflect associations mediated by the circulating cis protein, and the common trans-pQTLs are enriched for processes involving extracellular vesicles, highlighting a plausible mechanism for distal regulation of the levels of secreted proteins. Thus, our study generates a valuable resource of genetic associations linking variants to protein levels and disease in an understudied patient population to inform future studies of drug targets and physiology.
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