重编程
胶质瘤
生物
神经元
神经科学
转录因子
细胞生物学
细胞分化
神经干细胞
干细胞
癌症研究
细胞
遗传学
基因
作者
Xue-Yan Cheng,Zijian Tan,Xiao Huang,Yimin Yuan,Shangyao Qin,Yakun Gu,Dan Wang,Cheng He,Zhida Su
出处
期刊:Cells
[MDPI AG]
日期:2019-06-11
卷期号:8 (6): 571-571
被引量:27
摘要
Direct conversion of non-neural cells into induced neurons holds great promise for brain repair. As the most common malignant tumor in the central nervous system, glioma is currently incurable due to its exponential growth and invasive behavior. Given that neurons are irreversible postmitotic cells, reprogramming glioma cells into terminally differentiated neuron-like cells represents a potential approach to inhibit brain tumor development. We here show that human glioma cells can be directly, rapidly and efficiently reprogrammed into terminally differentiated neuron-like cells by the single transcription factor ASCL1 (Achaete-scute complex-like 1, also known as MASH1). These induced cells exhibit typical neuron-like morphology and express multiple neuron-specific markers. Importantly, ASCL1-mediated neuronal reprogramming drives human glioma cells to exit the cell cycle and results in dramatic inhibition of proliferation, both in vitro and in vivo. Taken together, this proof-of-principle study demonstrates a potential strategy for impeding brain tumor development by ASCL1-induced direct neuronal reprogramming.
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