基质血管部分
脂肪组织
医学
间质细胞
血管生成
嫁接
干细胞
吸收
间充质干细胞
外科
病理
内科学
细胞生物学
生物
有机化学
化学
聚合物
作者
Jack Brooker,J. Peter Rubin,Kacey G. Marra
出处
期刊:Journal of Craniofacial Surgery
[Ovid Technologies (Wolters Kluwer)]
日期:2019-05-01
卷期号:30 (3): 644-651
被引量:13
标识
DOI:10.1097/scs.0000000000005274
摘要
Abstract Fat grafting was first described in the early 20th century but for many years remained a relatively underused technique due to the unreliability of long-term volume expansion. Significant improvements in reliability have been made in the last 2 decades and there is a large body of literature pertaining to extraction, processing and injection methods to obtain more lasting effects. However, volume loss and graft resorption remain a major challenge in the long term and lead to unpredictability in results. Enriching adipose graft with stromal vascular fraction, ex vivo cultured adipose stem cells and platelet-derived growth factor among others is one method under active investigation which may assist graft survival through a range of mechanisms including increased angiogenesis. Breaking adipose graft into smaller fragments such that engrafted cells have greater access to donor-site oxygenation and nutrition is another method which in theory may promote survival. Presently, adipose grafting in the face is usually for the addition of volume to fill defects. However, the stem-cell containing fraction of adipose grafting (stromal vascular fraction) appears to exert a rejuvenating effect on overlying skin and soft tissue when administered alone. The application of these low-volume injections represents a significant shift in thinking away from mere volume expansion. These techniques have been tested in a range of animal models and some human studies. In this review, the authors provide a broad overview of present research and highlight both limitations in previous research and current areas of investigation.
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