光动力疗法
光敏剂
金丝桃素
化学
抗菌剂
甲苯胺酮
亚甲蓝
光化学
姜黄素
组合化学
卟啉
有机化学
生物化学
光催化
医学
药理学
催化作用
作者
Jaber Ghorbani,Dariush Rahban,Shahin Aghamiri,Alireza Teymouri,Abbas Bahador
出处
期刊:Laser therapy
[International Phototherapy Association]
日期:2018-12-28
卷期号:27 (4): 293-302
被引量:264
标识
DOI:10.5978/islsm.27_18-ra-01
摘要
Antibacterial Photodynamic therapy (APDT) is a process utilizing light and light sensitive agents (named photosensitizer (PS)) and is usually applied in an oxygen-rich environment. The energy of the photons is absorbed by the photosensitizer and subsequently transferred to surrounding molecules. Consequently, reactive oxygen species and free radicals are formed. These oxidative molecules can damage bacterial macromolecules such as proteins, lipids and nucleic acids and may result in bacterial killing. Unlike antibiotics, APDT as a novel technique does not lead to the selection of mutant resistant strains, hence it has appealed to researchers in this field. The type of PS used in APDT is a major determinant regarding outcome. In this review, various types of PS that are used in antimicrobial Photodynamic therapy will be discussed. PSs are classified based on their chemical structure and origin. Synthetic dyes such as methylene blue and toluidine blue are the most commonly used photosensitizers in Antibacterial Photodynamic therapy (APDT). Other photosensitizers including natural PSs (e.g. curcumin and hypericin) and tetra-pyrrole structures like phthalocyanines and porphyrins have also been studied. Furthermore, nanostructures and their probable contribution to APDT will be discussed.
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