肽YY
食欲
内分泌学
内科学
肠内分泌细胞
胰多肽
神经肽Y受体
下丘脑
刺激
生物
瘦素
胰高血糖素样肽-1
激素
化学
受体
内分泌系统
肥胖
神经肽
胰高血糖素
医学
糖尿病
2型糖尿病
作者
Carel W. le Roux,Steve Bloom
出处
期刊:Proceedings of the Nutrition Society
[Cambridge University Press]
日期:2005-05-01
卷期号:64 (2): 213-216
被引量:111
摘要
Obesity is taking on pandemic proportions. The laws of thermodynamics, however, remain unchanged, as energy will be stored if less energy is expended than consumed; the storage is usually in the form of adipose tissue. Several neural, humeral and psychological factors control the complex process known as appetite. Recently, a close evolutionary relationship between the gut and brain has become apparent. The gut hormones regulate important gastrointestinal functions such as motility, secretion, absorption, provide feedback to the central nervous system on availability of nutrients and may play a part in regulating food intake. Peptide YY (PYY) is a thirty-six amino acid peptide related to neuropeptide Y (NPY) and is co-secreted with glucagon-like peptide 1. Produced by the intestinal L-cells, the highest tissue concentrations of PYY are found in distal segments of the gastrointestinal tract, although it is present throughout the gut. Following food intake PYY is released into the circulation. PYY concentrations are proportional to meal energy content and peak plasma levels appear postprandially after 1 h. PYY 3-36 is a major form of PYY in both the gut mucosal endocrine cells and the circulation. Peripheral administration of PYY 3-36 inhibits food intake for several hours in both rodents and man. The binding of PYY 3-36 to the Y2 receptor leads to an inhibition of the NPY neurones and a possible reciprocal stimulation of the pro-opiomelanocortin neurones. Thus, PYY 3-36 appears to control food intake by providing a powerful feedback on the hypothalamic circuits. The effect on food intake has been demonstrated at physiological concentrations and, therefore, PYY 3-36 may be important in the everyday regulation of food intake.
科研通智能强力驱动
Strongly Powered by AbleSci AI