骨质疏松症
医学
发病机制
无症状的
干预(咨询)
骨重建
风险因素
疾病
骨病
骨密度
低雌激素
生物信息学
内分泌学
绝经后妇女
老化
骨量减少
生理学
内科学
骨矿物
生物
精神科
出处
期刊:Baillière's clinical rheumatology
[Elsevier]
日期:1993-10-01
卷期号:7 (3): 499-513
被引量:20
标识
DOI:10.1016/s0950-3579(05)80075-5
摘要
Osteoporosis is a disorder of ageing that shares with other disorders of ageing a multifactorial pathogenesis. The important factors for osteoporosis include the diet, life-style and intercurrent factors such as disease. However, it is clear that loss of ovarian function is an important determinant of bone loss, and oestrogen appears to be the key factor involved. Thus, not only does loss of ovarian function result in bone loss, it can be stopped by adequate oestrogen intervention. Numerous techniques are available to measure bone mass non-invasively and to estimate the risk of future fracture. Thus, for the postmenopausal woman who is concerned about osteoporosis, and who is willing to accept intervention to prevent the disease, bone mass measurement allows the clinician to determine the risk of future osteoporotic fracture and to provide intervention if required. Future studies may elucidate whether determination of skeletal remodelling using biochemistry adds significantly to risk determination. This may be required when considering agents other than oestrogen for intervention among asymptomatic women, as these agents primarily affect the skeleton, while the effects of oestrogen are wide ranging in the body.
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