路西法黄
锥体束
锥体细胞
解剖
树突棘
神经科学
生物
雷特综合征
癫痫
运动皮层
皮质(解剖学)
微量注射
大脑皮层
海马结构
内分泌学
生物化学
细胞内
刺激
基因
缝隙连接
细胞生物学
作者
Pavel V. Belichenko,Anders Oldfors,Bengt Hagberg,Annica Dahlström
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:1994-07-01
卷期号:5 (12): 1509-1513
被引量:215
标识
DOI:10.1097/00001756-199407000-00025
摘要
Autopsy material from three patients with Rett syndrome and six control cases (frontal, temporal and motor cortical areas) were studied. Pyramidal and non-pyramidal neurones, 100-200 in each specimen, were visualized by Lucifer Yellow microinjection. 3-D reconstructions and rotations were computed using the VoxelView/GT program. Various types of abnormalities in 3-D dendritic architecture of pyramidal neurones in different cortices were observed. Some pyramidal cells in layers II-III had a subnormal number of dendrites. The normally occurring specializations in pyramidal architecture in different cortical areas were absent. Decreased numbers and regional loss ('naked' areas) of dendritic spines were found. Widely distributed cortical afferents were shown by the carbocyanine dye (DiI) tracing method. PAD showed no microdysgenesis, in contrast to the observations in epilepsy.
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