川东北74
MHC I级
抗原处理
交叉展示
抗原呈递
主要组织相容性复合体
生物
CTL公司*
MHC II级
MHC限制
启动(农业)
细胞生物学
免疫学
C-C趋化因子受体7型
免疫系统
CD8型
T细胞
趋化因子
发芽
植物
趋化因子受体
作者
Genc Basha,Kyla Omilusik,Ana Chávez-Steenbock,Anna T. Reinicke,Nathan A. Lack,Kyung Bok Choi,Wilfred A. Jefferies
摘要
The invariant chain CD74 is involved in the formation of major histocompatibility complex class II. Jefferies and colleagues show that it also associates with class I in the endolysomal compartment and is important in cross-presentation. Immune responses are initiated and primed by dendritic cells (DCs) that cross-present exogenous antigen. The chaperone CD74 (invariant chain) is thought to promote DC priming exclusively in the context of major histocompatibility complex (MHC) class II. However, we demonstrate here a CD74-dependent MHC class I cross-presentation pathway in DCs that had a major role in the generation of MHC class I–restricted, cytolytic T lymphocyte (CTL) responses to viral protein– and cell-associated antigens. CD74 associated with MHC class I in the endoplasmic reticulum of DCs and mediated the trafficking of MHC class I to endolysosomal compartments for loading with exogenous peptides. We conclude that CD74 has a previously undiscovered physiological function in endolysosomal DC cross-presentation for priming MHC class I–mediated CTL responses.
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