Abstract The phytochemical investigation of the aerial parts of Siegesbeckia pubescens L. yielded 16 sesquiterpenoids, including a novel 11(7→6)abeo‐14‐norcarabrane sesquiterpenoid, pubescone ( 1 ), and a new germacrane sesquiterpene, 5 . The molecular structures of the isolated compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D‐ and 2D‐NMR.