Beneficial effects of Aesculus hippocastanum L. seed extract on the body's own antioxidant defense system on subacute administration

氧化应激 超氧化物歧化酶 抗氧化剂 丙二醛 过氧化氢酶 七叶树 传统医学 谷胱甘肽 医学 化学 药理学 食品科学 生物 内科学 生物化学 植物
作者
İsmail Küçükkurt,Sinan İnce,Hikmet Keleş,Esra Küpeli Akkol,Gülcan Avcı,Erdem Yeşilada,Elif Bacak
出处
期刊:Journal of Ethnopharmacology [Elsevier BV]
卷期号:129 (1): 18-22 被引量:62
标识
DOI:10.1016/j.jep.2010.02.017
摘要

Seeds of Aesculus hippocastanum L. have long been used in European phytotherapy to treat inflammatory and vascular problems. In Turkish folk medicine, tea prepared from the crushed seeds was used to pass kidney stone and against stomach ache, while a fraction of seed was swallowed to alleviate hemorroids symptoms. In order to evaluate the in vivo effects of escin mixture from Aesculus hippocastanum seed on the blood and tissue antioxidant defense systems in standard pellet diet (SPD) and in high-fat diet (HFD) consumed male mice. Escin mixture was obtained from the ethanol extract of seeds. Escin mixture was administered orally to male mice fed either standard pellet diet (SPD) or high-fat diet (HFD) at 100 mg/kg doses daily for 5 weeks and the tissue (liver, kidney and heart) and blood samples were collected at the end of experimental period. The effect of escin mixture on the plasma antioxidant activity; blood and tissue malondialdehyde (MDA) and reduced glutathione (GSH) levels; erythrocyte and tissue superoxide dismutase (SOD) and catalase activity (CAT) in SPD and HFD consumed animals were experimentally studied. Escin mixture prohibited the adverse effects of oxidative stress and showed a protective effect on the liver architecture both in SPD and HFD consumed male mice. Escin mixture prohibited the adverse effects of oxidative stress and showed a protective effect on the liver architecture both in SPD and HFD consumed male mice. Combined administration of high-fat diet with escin mixture decreased blood (p < 0.01), liver (p < 0.01), kidney (p < 0.05), and heart (p < 0.05) of MDA, liver SOD (p < 0.01) and CAT (p < 0.05) levels and increased blood (p < 0.01) and liver GSH (p < 0.001) levels in mice. The present results indicate that Aesculus hippocastanum increase the antioxidative defense system of the body and prevent HFD-induced lipid peroxidation in male mice.

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