鼻咽癌
生物
下调和上调
癌症研究
癌变
长非编码RNA
细胞生长
肝癌
癌症
细胞周期
肝细胞癌
细胞
细胞凋亡
基因
内科学
医学
遗传学
放射治疗
标识
DOI:10.1089/dna.2017.3686
摘要
Dysfunction of lncRNA has been found in the nasopharyngeal carcinoma (NPC); however, the effect of lncRNA expression on NPC tumorigenesis as well as the molecular mechanism of lncRNA in the pathogenesis of NPC remain largely unknown. In this study, we showed that highly upregulated in liver cancer (HULC), the first identified lncRNA in hepatocellular carcinoma, is highly expressed in NPC patients and correlated with a poor prognosis of cancer patients. Overexpressed HULC promotes NPC cell growth. Downregulation of HULC activated p53 and induced the increased expression of p21, which finally caused cell cycle arrest and cell apoptosis. These results suggested that HULC acts as an oncogenic lncRNA in NPC and a potential therapeutic target in NPC treatment.
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