Fermented egg-milk beverage alleviates dextran sulfate sodium-induced colitis in mice through the modulation of intestinal flora and short-chain fatty acids

毛螺菌科 盲肠 结肠炎 溃疡性结肠炎 炎症 细菌 肠道菌群 地穴 乳酸菌 短链脂肪酸 食品科学 化学 发酵 微生物学 生物 生物化学 免疫学 内科学 医学 疾病 内分泌学 厚壁菌 丁酸盐 遗传学 16S核糖体RNA
作者
Siwen Lyu,Fengguang Pan,Huifang Ge,Qi Yang,Xuehui Duan,Mengmeng Feng,Xuanting Liu,Ting Zhang,Jingbo Liu
出处
期刊:Food & Function [The Royal Society of Chemistry]
卷期号:13 (2): 702-715 被引量:11
标识
DOI:10.1039/d1fo03040j
摘要

Fermented egg-milk beverage (FEMB) can alleviate the symptoms of intestinal diseases by regulating intestinal flora and supplying nutrition. This study investigated the protective effect of FEMB on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. The results showed that FEMB relieved the UC mice's pathological abnormalities and colonic inflammation, and restructured the intestinal flora composition simultaneously. After FEMB treatment for 14 days, the body weight of the mice rose and the disease activity index (DAI) value decreased. Furthermore, the length and form of colons in the UC mice were notably restored. Inflammatory cells decreased or disappeared, and goblet cells and crypt were enriched and modified. 16S rRNA gene sequencing results demonstrated that FEMB treatment could increase the abundance of beneficial bacteria in the cecum content of mice, including unclassified_f_Lachnospiraceae and Lactobacillus. Moreover, probiotics that can increase the content of short-chain fatty acids (SCFAs) may contribute to inflammation alleviation. An increase in amino acids was observed in our experiment, which may benefit nutritional supplements. In conclusion, FEMB treatment can alleviate the damage of DSS-induced colitis in Balb/c mice. This study provides a theoretical basis for both the relief of inflammation and the application of FEMB.
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