新生血管
黄斑变性
脉络膜新生血管
血管内皮生长因子
微泡
视网膜
视网膜
抗体
癌症研究
医学
血管生成
免疫学
生物
化学
眼科
血管内皮生长因子受体
神经科学
生物化学
小RNA
基因
作者
Ying Tian,Fan Zhang,Yefeng Qiu,Shuang Wang,Feng Li,Jiawei Zhao,Chao Pan,Yong Tao,Di Yu,Wei Wei
标识
DOI:10.1038/s41551-021-00764-3
摘要
Choroidal neovascularization induced by age-related macular degeneration and retinal neovascularization induced by diabetic retinopathy-two leading causes of blindness-are often treated using antibodies targeting vascular endothelial growth factor (VEGF). Here we report a strong association between inflammation and high VEGF expression in aqueous humour samples from patients with choroidal or retinal neovascularization, and show that intravitreally injected exosomes derived from regulatory T cells and conjugated with an anti-VEGF antibody via a peptide linker that is cleavable by matrix metalloproteinases markedly suppressed ocular neovascularization in mouse and non-human primate models of choroidal neovascularization. The engineered exosomes, which selectively accumulate in the neovascularization lesions, could be adapted for other combination therapies of therapeutic antibodies and anti-inflammatory cargo.
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