萎缩性胃炎
小檗碱
内科学
代谢组学
医学
尿
机制(生物学)
肿瘤坏死因子α
治疗效果
炎症
药理学
细胞因子
胃炎
化学
胃
色谱法
认识论
哲学
作者
Yuling Tong,Xu Zhao,Ruilin Wang,Ruisheng Li,Wenjun Zou,Yanling Zhao
标识
DOI:10.1016/j.ejphar.2021.174335
摘要
The purpose of this study was to investigate the therapeutic effect of berberine (BBR) on chronic atrophic gastritis (CAG) and its potential mechanism. The effects of BBR on gastric histopathology, serum biochemical indexes and inflammatory factors in CAG rats were assessed. Moreover, plasma and urine metabolomics based on ultra high performance liquid chromatography-quadrupole-time-of-flight mass spectrometer (UHPLC-Q-TOF/MS) were used to identify potential metabolic markers and possible pathways of BBR in the treatment of CAG. The results showed that BBR could significantly improve the pathological characteristics of gastric tissue, alleviate the serum biochemical indexes and reduce the mRNA expression of nuclear factor-κB, tumor necrosis factor-α, Cyclooxygenase-2, monocyte chemoattractant protein-1, Interleukin-17A and I interferon-γ. The results of metabolomic analysis show that the therapeutic effect of BBR on CAG may be related to the regulation of 15 metabolic markers and 12 metabolic pathways, which may be the potential mechanism for the treatment of CAG. This study provides new insights for elucidating the mechanism of BBR improving CAG.
科研通智能强力驱动
Strongly Powered by AbleSci AI