Triterpene Saponins from Bacopa monnieri and Their Antidepressant Effects in Two Mice Models

Three new triterpene glycosides, bacopasides VI−VIII (1−3), together with three known analogues, bacopaside I (4), bacopaside II (5), and bacopasaponsin C (6), were isolated from the whole plant of Bacopa monnieri. Compounds 4, 5, and 6 showed antidepressant activity when tested on forced swimming and tail suspension in mice, respectively.