生物相容性
药物输送
固体脂质纳米粒
纳米技术
灵活性(工程)
药品
毒品携带者
材料科学
化学
药理学
医学
数学
统计
冶金
作者
Archana Khosa,Satish Reddi,Ranendra Narayan Saha
标识
DOI:10.1016/j.biopha.2018.04.055
摘要
Nanostructured lipid carriers (NLC), comprises of a blend of solid and liquid lipids which results in a partially crystallized lipid system and imparts many advantages over solid lipid nanoparticles such as enhanced drug loading capacity, drug release modulation flexibility and improved stability. NLC have found numerous applications in both pharmaceutical and cosmetic industry due to ease of preparation, the feasibility of scale-up, biocompatibility, non-toxicity, enhanced targeting efficiency and the possibility of site-specific delivery via various routes of administration. This review highlights the NLC with focus on the structure, the various fabrication techniques used and the characterization techniques which are critical in the development of a suitable and stable formulation. The review also provides an insight into the potential of NLC as site-specific delivery systems and the therapeutic applications explored via various routes of administration.
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