吡啶
化学
抗菌剂
荧光
组合化学
稻黄单胞菌
抗菌化疗
分子
生物测定
作用机理
立体化学
抗菌活性
结构-活动关系
生物活性
生物化学
有机化学
体外
生物
物理
基因
量子力学
遗传学
作者
Jian Zhou,Qing-Qing Tao,Pei-Yi Wang,Wu-Bin Shao,Zhi-Bing Wu,Zhong Li,Song Yang
标识
DOI:10.1016/j.bmcl.2018.04.034
摘要
A type of pyridinium-decorated 1,4-pentadien-3-one derivatives possessing flexible alkyls were designed and synthesized by integrating the key scaffolds of pyridinium cations and 1,4-pentadien-3-one skeleton in a single molecular architecture. Antimicrobial bioassays indicated that some of the target molecules exerted considerable bioactivities against six phytopathogenic strains, especially for Xanthomonas oryzae pv. oryzae, the minimal EC50 value can reach to 0.504 µg/mL. A plausible action mechanism for this kind of compounds was proposed and confirmed by employing fluorescent spectroscopy, fluorescence microscopy, and scanning electron microscopy. We anticipated that this finding can promote high-efficient lead compounds discovery in the research of antimicrobial chemotherapy.
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