跳跃
生物
发育生物学
神经科学
业务
遗传学
财务
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2008-08-29
卷期号:321 (5893): 1169-1170
被引量:5
标识
DOI:10.1126/science.1163475
摘要
There has been substantial progress in defining the primary molecular defects causing inherited forms of major neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and Parkinson's disease. However, developing therapies for these diseases has been hindered by several experimental limitations, including the absence of in vitro models that accurately reproduce the genetic milieu of the disease and inadequate systems to dissect the roles of diverse cell types in the pathogenesis of these diseases. On page 1218 in this issue, Dimos et al. (1) demonstrate that new technologies in stem cell biology may overcome these barriers by reprogramming adult fibroblasts into embryonic stem cells that can subsequently yield patient-specific neural cells (neurons and astroglial cells) (1). The study focuses on ALS, but the findings are applicable to diverse neurological diseases.
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