炎症
激酶
疾病
癌症研究
生物信息学
计算生物学
免疫学
化学
医学
生物
内科学
生物化学
作者
Divya Chaudhary,Shaughnessy Robinson,Donna L. Romero
摘要
IRAK4, a serine/threonine kinase, plays a key role in both inflammation and oncology diseases. Herein, we summarize the compelling biology surrounding the IRAK4 signaling node in disease, review key structural features of IRAK4 including selectivity challenges, and describe efforts to discover clinically viable IRAK4 inhibitors. Finally, a view of knowledge gained and remaining challenges is provided.
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