重编程
基因组印记
体外成熟
卵母细胞
DNA甲基化
表观遗传学
生物
体外受精
男科
甲基化
细胞生物学
胚胎
遗传学
基因
医学
基因表达
出处
期刊:Chin J Reprod Contracep
日期:2019-09-25
卷期号:39 (9): 768-771
标识
DOI:10.3760/cma.j.issn.2096-2916.2019.09.014
摘要
In vitro maturation (IVM) of oocytes, a frontier technique in in vitro fertilization (IVF) field, specifically targeting at some infertile patients with egg maturation disorders, have been introduced into the clinical assisted reproductive technology. It is a mild approach to replace conventional ovarian stimulation for polycystic ovary syndrome (PCOS) patients and has advantages of reducing the burden and cost of treatment. However, it is noteworthy that oocyte culture may interfere with epigenetic reprogramming of the development process, leading to birth defects in the offspring. This review will talk about impression of IVM on expression of imprinted genes, early embryonic development and imprinted gene methylation and impression of embryo culture on the methylation.
Key words:
In vitro maturation; Assisted reproduction; Imprinted gene; DNA methylation
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