Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials

医学内科学羟基氯喹美罗华队列安慰剂临床试验类风湿性关节炎物理疗法疾病病理替代医学传染病（医学专业）淋巴瘤 2019年冠状病毒病（COVID-19）

作者

Jessica Tarn,Nadia Howard-Tripp,Dennis Lendrem,Xavier Mariette,Alain Saraux,Valérie Devauchelle‐Pensec,Raphaèle Séror,Andrew Skelton,Katherine James,Peter McMeekin,Shereen Al-Ali,Katie L. Hackett,Clare Lendrem,Ben Hargreaves,John Casement,Sheryl Mitchell,Simon J Bowman,Elizabeth Price,Colin S. Gillespie,Paul Emery,Peter Lanyon,John Hunter,Monica Gupta,Stefano Bombardieri,Nurhan Sutcliffe,Costantino Pitzalis,John D Pauling,Annie Cooper,Marian Regan,Ian Giles,David Isenberg,V. Saravanan,David Coady,Bhaskar Dasgupta,Neil McHugh,Katherine Siminovitch,Robert J. Moots,Nagui Gendi,Mohammed Akil,Bridget Griffiths,Svein Joar Auglænd Johnsen,Katrine Brække Norheim,Marie Wahren‐Herlenius,Deborah Stocken,Colin Everett,Catherine Fernandez,John D. Isaacs,Jacques‐Eric Gottenberg,Wan‐Fai Ng,Valérie Devauchelle‐Pensec,Philippe Dieudé,Jean Jacques Dubost,Vincent Goëb,Vincent Goëb,É. Hachulla,C. Larroche,Véronique Le Guern,Jacques Morel,Aleth Perdriger,Xavier Puéchal,S. Rist,Damien Sen,Élodie Perrodeau,Olivier Vittecoq,Joëlle Bénessiano,Sarah Tubiana,Stanie Gaëte,Stanie Gaete,Djilali Batouche,Domitille Molinari,Mickael Randrianandrasana,Isabelle Pane,Adeline Abbé,Gabriel Baron,Philippe Ravaud,Jacques-Eric Gottenberg,Philippe Ravaud,Xavier Puéchal,Véronique Le Guern,Élodie Perrodeau,C. Larroche,Alain Saraux,Valérie Devauchelle-Pensec,Jacques Morel,Claire Hulme,P.Y. Hatron,Aleth Perdriger,Damien Sene,Charles Zarnitsky,Djilali Batouche,Valérie Furlan,Joëlle Bénessiano,Elodie Perrodeau,Raphaèle Séror,Xavier Mariette,Samuel M. Brown,Nicolás Cuenca Navarro,Saaeha Rauz,Paul Emery,Sue Pavitt,J Gray,Claire Hulme,F Hall,R Busch,P. Smith,Charles Zarnitsky,Stefano Bombardieri,W-F Ng,C Pease,Elizabeth Price,Nurhan Sutcliffe,Clodagh Woods,Jacqueline Andrews,Colin Everett,Catherine Reynolds,Elizabeth A. Skinner,A Poveda-Gallego,John Rout,Iain MacLeod,Saaeha Rauz,Simon Bowman,Wan‐Fai Ng,Simon J Bowman,Bridget Griffiths,Frances Hall,Elalaine C Bacaba,Helen Frankland,Robert J. Moots,Kuntal Chadravarty,Shamin Lamabadusuriya,Stefano Bombardieri,Constantino Pitzalis,Nurhan Sutcliffe,Celia Breston,Nagui Gendi,Karen Culfear,Claire Riddell,J Hamburger,Andrea Richards,Saaeh Rauz,S Brailsford,Joanne Dasgin,Joanne Logan,D. Mulherin,Jacqueline Andrews,P. Emery,Alison McManus,Colin S. Gillespie,David Pickles,Alison Booth,Marian Regan,Jon King Kin,Amanda Holt,Theodoros Dimitroulas,Lucy Kadiki,Daljit Kaur,Theodoros Dimitroulas,Abdul Haque Khan,Tracey Cosier,Panthakalam,Anne Field,Mark Lloyd,Laurence Moore,Esther Gordon,Cathy Lawson,Monica Gupta,John Hunter,Lesley Stirton,G. Torres Ortiz,Elizabeth Price,Suzannah Pelger,Claire Gorman,Balinder Hans,Gavin Clunie,Suzanne Lane,Ginny Rose,Sue Cuckow,Michael Batley,Joanne Dasgin,Susan Knight,Deborah Symmons,Beverley Jones,Stefano Fedele,Suzanne Edgar,Francisco Figuereido,H. Foggo,Dennis Lendrem,Iain MacLeod,Sheryl Mitchell,Christine Downie,Jessica Tarn,James Locke,Shereen Al-Ali,Sarah Legg,Kamran Mirza,Ben Hargreaves,Theodoros Dimitroulas,Adrian Jones,Peter Lanyon,Alice Muir,Paula White,Katherine Siminovitch,Abdul Haque Khan,V. Saravanan,Annie Cooper,Marianne Watkins,Anne Field,Stephen B. Kaye,Devesh Mewar,Patricia Medcalf,Pamela Tomlinson,David Whiteside,Neil McHugh,John D Pauling,Julie James,Amy Dowden,Mohammed Akil,Jayne McDermott,Olivia Godia,David Coady,Elizabeth Kidd,Lynne Palmer,Gavin Clunie,Sarah Bartrum,D Mead,Bhaskar Dasgupta,Victoria Katsande,Pamela O. Long,Erin Vermaak,J. Turner,Usha Chandra,Kirsten Mackay,Stefano Fedele,Ada Ferenkeh-Koroma,Ian Giles,David Isenberg,Helena MaConnell,Nyarko Ahwiren,C Scully,Paul Allcoa,John D Pauling

出处

期刊：The Lancet Rheumatology [Elsevier]
日期：2019-09-25 卷期号：1 (2): e85-e94 被引量：92

链接

thelancet.com archives-ouvertes.fr hal.science ac.uk ac.uk ac.uk ac.uk ac.uk nih.gov ac.uk nih.govdoi.org

标识

DOI：10.1016/s2665-9913(19)30042-6

摘要

Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relate these differences to pathobiology and therapeutic response.

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Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials

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