表观遗传学
组蛋白
癌症表观遗传学
DNA甲基化
癌症研究
乙酰化
癌症
生物信息学
表观遗传疗法
生物
遗传学
基因
组蛋白甲基转移酶
基因表达
作者
Cheng Yuan,He Cai,Manni Wang,Xuelei Ma,Fei Mo,Shengyong Yang,Junhong Han,Xiawei Wei
标识
DOI:10.1038/s41392-019-0095-0
摘要
Abstract Epigenetic alternations concern heritable yet reversible changes in histone or DNA modifications that regulate gene activity beyond the underlying sequence. Epigenetic dysregulation is often linked to human disease, notably cancer. With the development of various drugs targeting epigenetic regulators, epigenetic-targeted therapy has been applied in the treatment of hematological malignancies and has exhibited viable therapeutic potential for solid tumors in preclinical and clinical trials. In this review, we summarize the aberrant functions of enzymes in DNA methylation, histone acetylation and histone methylation during tumor progression and highlight the development of inhibitors of or drugs targeted at epigenetic enzymes.
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