膨胀的
转移
选择性拼接
抗药性
RNA剪接
癌症研究
信使核糖核酸
癌症
生物
生物信息学
医学
计算生物学
遗传学
基因
核糖核酸
材料科学
抗压强度
复合材料
作者
Akram Alkrekshi,Wei Wang,Priyanka S. Rana,Vesna Markovic,Khalid Sossey‐Alaoui
标识
DOI:10.1016/j.cellsig.2021.110073
摘要
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain protein family with multifunctional properties both in the cytoplasm and inside the nucleus. YB-1 is also involved in various cellular functions, including regulation of transcription, mRNA stability, and splicing. Recent studies have associated YB-1 with the regulation of the malignant phenotypes in several tumor types. In this review article, we provide an in-depth and expansive review of the literature pertaining to the multiple physiological functions of YB-1. We will also review the role of YB-1 in cancer development, progression, metastasis, and drug resistance in various malignancies, with more weight on literature published in the last decade. The methodology included querying databases PubMed, Embase, and Google Scholar for Y box binding protein 1, YB-1, YBX1, and Y-box-1.
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