生物
基因组
表观遗传学
进化生物学
染色质
表观遗传学
现存分类群
遗传学
基因组进化
染色体
基因
DNA甲基化
基因表达
作者
Zhenhui Wang,Xinfeng Wang,Tianyuan Lu,Ming-Rui Li,Peng Jiang,Jing Zhao,Sitong Liu,Xueqi Fu,Jonathan F. Wendel,Yves Van de Peer,Liu B,Linfeng Li
标识
DOI:10.1038/s41467-022-29561-5
摘要
All extant core-eudicot plants share a common ancestral genome that has experienced cyclic polyploidizations and (re)diploidizations. Reshuffling of the ancestral core-eudicot genome generates abundant genomic diversity, but the role of this diversity in shaping the hierarchical genome architecture, such as chromatin topology and gene expression, remains poorly understood. Here, we assemble chromosome-level genomes of one diploid and three tetraploid Panax species and conduct in-depth comparative genomic and epigenomic analyses. We show that chromosomal interactions within each duplicated ancestral chromosome largely maintain in extant Panax species, albeit experiencing ca. 100-150 million years of evolution from a shared ancestor. Biased genetic fractionation and epigenetic regulation divergence during polyploidization/(re)diploidization processes generate remarkable biochemical diversity of secondary metabolites in the Panax genus. Our study provides a paleo-polyploidization perspective of how reshuffling of the ancestral core-eudicot genome leads to a highly dynamic genome and to the metabolic diversification of extant eudicot plants.
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